• The aim of the following work was to untap

  2020-09-21

  

  The aim of the following work was to untap the potential of DIS as a low-cost substrate for fungal production of lignocellulolytic enzymes via SSF. Fungal strains with the ability to transform the unpretreated DIS to a mixture of industrially relevant lignocellulases were identified. Furthermore, th

• br Advent of SMEPT br

  2020-09-21

  

  Advent of SMEPT SMEPT for localized synthesis of nitric oxide Critical evaluation and outlook Examples discussed in this review present SMEPT as a methodology for localized drug synthesis – a unique opportunity for site specific therapeutic interventions using implantable biomaterials. This

• In agreement with the evidence on the Plg binding

  2020-09-21

  

  In agreement with the evidence on the Plg-binding function of tapeworm enolases, eukaryotic enolases have been shown to be multifunctional proteins, with other activities besides their role as glycolytic enzymes (Pancholi, 2001). In this respect, several flatworms have been proved to express enolas

• Enhanced responses to varying concentrations of bronchoconst

  2020-09-21

  

  Enhanced responses to varying concentrations of bronchoconstrictors, such as MCh, and airway obstruction are characteristic of angiotensin ii and common to other clinical states, including chronic obstructive pulmonary disease, lung transplantation, and infection- or chemical agent-induced airway i

• br Results br Discussion CCA is

  2020-09-21

  

  Results Discussion CCA is a fatal tumor originating from the intrahepatic bile duct and the prognosis is very poor (Hoyos et al., 2018). CCA is one of the most dangerous primary liver malignant tumors and the most common malignant tumor of the biliary tract worldwide. However, the underlying m

• OHC is a potent regulator of LXR

  2020-09-21

  

  25-OHC is a potent regulator of LXR-mediated pathways, that impact on pkd kinase lipid homeostasis [8]. This oxysterol affects expression of the cholesterol efflux pumps ATP-binding cassette transporter (ABC)A1 [9] and ABCG1, and expression of apolipoprotein E [10], [11], [12]. 25-OHC is able to sti

• Accordingly we prepared three compounds and as

  2020-09-21

  

  Accordingly, we prepared three compounds (, , and ) as shown in . Condensation of commercially available INCB 018424 with glycine methyl ester gave amide . A Friedel–Crafts reaction between compound and 4-methyl valeryl chloride in the presence of aluminum chloride mainly produced undesired comp

• The lack of effective strategies aiming to directly increase

  2020-09-21

  

  The lack of effective strategies, aiming to directly increase the neuronal survival, is reflected by the fact that the only available therapeutic interventions are indirect. They consist of acute therapeutic interventions involving chemical and/or surgical removal of the thrombotic clot (Taqi et al.

• The occurrence of three Ag NORs

  2020-09-21

  

  The occurrence of three Ag-NORs per metaphase and/or a maximum of three nucleoli per nucleus in most of the varieties may be explained by chromosomal rearrangements or unequal crossing-over events that induce the deletion of the fourth active rDNA loci. Also, the chromosome pair that showed less int

• A novel series of DHODH inhibitors was

  2020-09-21

  

  A novel series of DHODH inhibitors was developed by us based on a lead that was discovered during a docking procedure and medicinal chemistry exploration. The activity of the initial lead was improved by a QSAR method and yielded low nanomolar inhibitors. Introduction The most common metabolic h

• The homologous DDRs are composed of an N

  2020-09-21

  

  The homologous DDRs are composed of an N-terminal discoidin homology domain, followed by a sequence of ∼220 amino acids unique to the DDRs, a transmembrane domain, a large juxtamembrane domain, and a conserved cytoplasmic tyrosine kinase domain. In a previous study, we demonstrated that DDR activati

• In general accurate results for the prediction of the

  2020-09-19

  

  In general, accurate results for the prediction of the solubility in scCO2 + cosolvents using the CPA-EoS were verified. ALD values for each solute (Table 1) varied from 0.04 to 1.5. Few solutes, such as lauric acid, myristic acid, hydroquinone and salicylic acid, presented the highest ALD values. A

• br Outcome of COX overexpression Although a causal role for

  2020-09-19

  

  Outcome of COX-2 overexpression Although a causal role for COX-2 has been proposed, mechanisms by which COX-2 function contributes to the pathogenesis of hyperplastic disease are not well defined. To examine if there is any correlation between COX-2 and p53 protein levels, Kumagai et al. [15] rec

• Cardiogenesis is enhanced with timely applicati

  2020-09-19

  

  Cardiogenesis is enhanced with timely application of Wnt pathway activators and inhibitors. A combination of Wnt/β-catenin signaling pathway activators such as CHIR99021 and inhibitors such as IWP-2 and IWR-1 have been found to be highly efficient cardiomyocyte differentiation protocols [27], [28].

• br Effects of estrogens on bone Estrogens play

  2020-09-19

  

  Effects of estrogens on bone Estrogens play an important role in bone remodeling, as demonstrated by studies in mice in which the ER genes were deleted [21], [22]. ERβ compensates for the BAN ORL 24 australia of ERα, and vice versa, but when both ERs are deleted a profound decrease in trabecular

15515 records 814/1035 page Previous Next First page 上5页 811812813814815 下5页 Last page