• br Collagens as new drivers of zebrafish tissue

  2020-07-11

  

  Collagens as new drivers of zebrafish tissue regeneration Contrary to mammals, zebrafish possess very high regeneration capacities and thereby represent a versatile model to study tissue and organ regeneration. Adult fish can fully reconstruct their brain, spinal cord, retina, kidney, liver, panc

• The instructive precedent for galectin phosphorylation

  2020-07-11

  

  The instructive precedent for galectin phosphorylation is human galectin-3 (hGal-3). Its serine modification by protein kinase CK1 in the N-terminal tail is relevant for nuclear export during the course of apoptosis regulation and contact formation with the neural cell adhesion molecule L1 , , , . T

• br Experimental section br Acknowledgments This work was sup

  2020-07-11

  

  Experimental section Acknowledgments This work was supported by the National Natural Science Foundation of China (NSFC, Grant No. 81573285 and No. 81602965), the Natural Science Basic Research Plan in Shaanxi Province of China (Program No. 2018JM7071 and No. 2017JQ8002), and the Fundamental Re

• br Funding This work was supported by intramural

  2020-07-11

  

  Funding This work was supported by intramural funding of the Department of Internal Medicine I-Cardiology, University Hospital Aachen, RWTH Aachen. Acknowledgments Introduction Cyclic adenosine monophosphate (cAMP) is a central second messenger that controls a plethora of vital functions.

• Methods br Results First we compared A plaque number

  2020-07-11

  

  Methods Results First, we compared Aβ plaque number, Aβ concentration, and neurobehavior functions between naive APP/PS1 and APP/PS1xEP1−/− mice. Significantly lower Aβ burden in APP/PS1xEP1−/− mice was evidenced by fewer plaques in the hippocampal area and a lower concentration of soluble Aβ42

• br Materials and methods br

  2020-07-11

  

  Materials and methods Results Discussion In this study, we employed a liquid chromatography mass spectrometry (LC–MS)-based metabolomic approach to profile GEF metabolism and bioactivation in human and mouse liver microsomes. Metabolomic approaches rendered us readily screen out the GEF-rel

• While SCF E ligase activity was reconstituted with

  2020-07-11

  

  While SCF E3 ligase activity was reconstituted with recombinant proteins two decades ago, the ability to probe APC/C was limited until recently because of its behemoth size. Human APC/C is a 1.2-MDa assembly comprised of 19 core subunits (one each of nine different APC subunits, and two each of five

• m6A The preceding results show no association between the EP

  2020-07-10

  

  The preceding results show no association between the EP1 gene polymorphisms and suicide completers in the Japanese population. Impulsive aggression is one of the most important risk factors for suicide especially in the younger generation (Brent et al., 2002, Melhem et al., 2007). EP1 knockout mice

• Indeed the alkyl group is not seen in the original

  2020-07-10

  

  Indeed, the -alkyl group is not seen in the original crystallographic electron density omit map prior to positioning either inhibitor in DHODH, nor can it be found in the final maps. Rather, the electron density maps are consistent with hydrolysis of the amide to the acid. Once the scaffold was clea

• For the SAR optimization of the right hand side it

  2020-07-10

  

  For the SAR optimization of the right hand side, it was decided to explore the inclusion of the key carboxylic Arylquin 1 moiety present in the original DGAT-1 inhibitors from . Analogs were constructed by the synthetic routes outlined in , . In , the methylene-oxy linker was introduced by condensat

• dna ligase br Introduction Accounting educators and

  2020-07-10

  

  Introduction Accounting educators and professional accounting organizations have speculated that advanced placement (AP) may be an effective tool for recruiting high-quality students into accounting education programs (Deines, Bittner, & Eichman, 2012; The Pathways Commission, 2012), and it is no

• OxLDL down regulates eNOS and up

  2020-07-10

  

  OxLDL down-regulates eNOS and up-regulates iNOS, thereby augmenting the formation of NO and protein S-nitrosylation in human endothelial Cy5.5 maleimide (non-sulfonated) [26]. Importantly, iNOS-mediated S-nitrosylation plays an increasingly significant role in cardiovascular diseases [34]. For exam

• Our previous work has demonstrated that two glutamate residu

  2020-07-10

  

  Our previous work has demonstrated that two glutamate residues (Glu-305 and Glu-331 in murine and human TPP II) in the active site are important for exopeptidase activity in mTPP II [17]. At least one of these, Glu-331, seems to form a salt bridge to the N-terminal amino group of the substrate, posi

• br Activatable MRI probes MRI

  2020-07-09

  

  Activatable MRI probes MRI is commonly used in clinics around the world and has the advantages of outstanding tissue-penetration depth and extremely high spatial resolution for in vivo imaging [33]. MRI has relatively poor sensitivity and usually requires ganciclovir synthesis agents to enhance t

• Recoverin is a kDa retinal protein that binds

  2020-07-09

  

  Recoverin is a 23-kDa retinal protein that binds to calcium. It regulates the Pifithrin-α of rhodopsin during visual transduction within photoreceptor cells. Since the pathogenicity of anti-recoverin antibody is potent, anti-recoverin CAR patients often have progressive visual impairments, characte

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