• It has been reported that

  2021-05-12

  

  It has been reported that the ECD of DDRs require dimerization and/or oligomerization for binding to collagen.,, Here, we have established using SPR that antibody-mediated oligomerization of DDR2-Fc significantly enhances its binding to immobilized collagen type 1. Our results are consistent with ea

• From these and other studies it is clear that

  2021-05-12

  

  From these and other studies, it is clear that acriflavine is an interesting N1-Methyl-ATP with pleiotropic anticancer effects [21], [22], [43]. Its past systemic use in the clinical setting as an antibiotic without any major toxicity reported encourages further development of the drug for cancer t

• SR 59230A hydrochloride Our approach including the character

  2021-05-12

  

  Our approach, including the characterization of histone modifications in scarce NK subsets, allowed us to identify super-enhancers, which associate with genes endowing a given cell type with its unique identity (Hnisz et al., 2013). Especially intriguing were SEs with distinct activities in NK subse

• Concholepas concholepas our model species for this

  2021-05-12

  

  Concholepas concholepas, our model species for this study, is a marine gastropod found along the Chilean coast that has become commercially important [25], [26], [27]. Until now, the main focus of immunology related to C. concholepas is the production of a novel hemocyanin that has been useful for t

• br Conclusion The role of DNA PK target

  2021-05-12

  

  Conclusion The role of DNA-PK target in DNA DSB repair renders this thiostrepton kinase of great medicinal interest in cancer chemotherapy especially the cancer types of linked to DNA defects. Due to the absence of 3D DNA-PK target structure, different ligand-based methods were applied for desig

• ABH expression is elevated in prostate carcinomas and

  2021-05-12

  

  ABH3 expression is elevated in prostate carcinomas and has been referred to as prostate cancer antigen-1 or PCA-1. ABH3/PCA-1 was proposed as a diagnostic marker for prostate cancers, and suggested as a possible therapeutic target [82]. However, the recent studies of ABH2 and ABH3-null mice indicate

• br Materials and Methods br Results

  2021-05-12

  

  Materials and Methods Results Discussion HSCs have been identified as major collagen-producing nelfinavir in the injured liver (1), and activation of HSCs has become the central link for liver fibrosis (2). The factors that regulate the biological behavior of HSCs include soluble regulatory

• Cultured cells or mouse lung tissues were harvested and

  2021-05-12

  

  Cultured cells or mouse lung tissues were harvested and lysed in Radio-Immunoprecipitation Assay (RIPA) buffer (0.05 mol/l Tris–HCl pH 7.4, 0.15 mol/l NaCl, 0.25% deoxycholic acid, 1% NP-40, 1 mmol/l ethylenediamine tetraacetic SynaptoRedTM C2 (EDTA), 1 mmol/l phenylmethylsulfonyl fuoride, 1 μg/ml

• Our results suggest that formation of DDR b

  2021-05-12

  

  Our results suggest that formation of DDR1b clusters may be important for and precede receptor phosphorylation. Indeed, while DDR1b clustering was readily detected (by YFP signal) 30 min after collagen administration, phosphorylated DDR1 species at Y513 (present in the IJXM) were evident after 4 h o

• The all NTP pyrophosphatase and NUDIX families

  2021-05-12

  

  The all-α NTP pyrophosphatase and NUDIX families maintain the deoxynucleotide triphosphate (dNTP) pool balance, limit the incorporation of harmful nucleotides, and represent a promising therapeutic approach to develop anticancer and immunosuppressive agents., , , , Among these housekeeping enzymes

• In present study we measured the

  2021-05-12

  

  In present study, we measured the methylation and 81 5 levels of CDKL2 in HCC tissues and cell lines. Meanwhile, correlations between the methylation and mRNA expression, clinicopathological features were evaluated. Materials and methods Results Discussion DNA methylation is a heritable e

• It has been reported that NMDA

  2021-05-12

  

  It has been reported that NMDA receptor hypofunction upregulates the expression of immediate early genes in several simvastin regions [39], [40]. Consistent with this finding, we demonstrated that MK-801 increased the number of c-Fos-positive cells in the PVN and PC/RS (Fig. 5). Importantly, the MK

• In order to further evaluate

  2021-05-12

  

  In order to further evaluate cpt1a function, we determined its tissue distribution in large yellow croaker. The mRNA levels of cpt1a were detected in all the tested tissues, but at varying levels. cpt1a mRNA expression was the highest in liver among different tissues, similar to reports in other fis

• The current study showed that the tested nonselective COX in

  2021-05-12

  

  The current study showed that the tested nonselective COX inhibitors potentiated the neuronal (EFS) and endothelial (ACh)-dependent relaxation of rat corpus cavernosum. Indomethacin was the most effective among them in potentiating EFS-induced relaxation. Diclofenac was the most effective in potenti

• Chk is dramatically induce by the IL

  2021-05-11

  

  Chk is dramatically induce by the IL-4 family of cytokines and equally dramatically inhibited by IFN-γ, a regulation that appears to be specific for human monocytes. In primary human T cells, Chk is not normally present, but it can be induced by potent activators of T 76 7 such as PHA or IL-2 ((McVi

15063 records 654/1005 page Previous Next First page 上5页 651652653654655 下5页 Last page