• The simple carrier model for GLUT transport activity propose

  2021-10-29

  

  The simple carrier model for GLUT1 transport activity proposes that the transporter alternates between an outward facing glucose binding site and an inward, cytoplasmic, facing glucose binding site. Cytochalasin B is an endofacial inhibitor and appears to preferentially bind to the open, inward fac

• GKRP binds to the inactive super open conformation

  2021-10-29

  

  GKRP binds to the inactive, super-open conformation of GCK, acting as a competitive inhibitor of glucose association with the enzyme (Fig. 3) [45]. Upon formation of the inhibitory complex with GKRP, GCK is sequestered into the hepatocyte nucleus [48]. The detailed mechanism by which GKRP mediates t

• br Material and methods br Results

  2021-10-29

  

  Material and methods Results Discussion Accumulating evidence suggests that the hippocampus is sensitive to noise-induced hearing loss and other forms of sensory deprivation, which deprives the hippocampus of sensory information required for its normal operations such as spatial navigation

• Clinical trials of all GSIs

  2021-10-29

  

  Clinical trials of all GSIs have ended prematurely, raising the question on our understanding of their target, the γ-secretase/presenilin. Development of compounds to target γ-secretase and reduce Aβ production is complicated by the fact that γ-secretase/presenilin has critical biological function,

• The GH family has potential applications in various industri

  2021-10-29

  

  The GH family has potential applications in various industries. A putative ORF encoding α-galactosidase, namely GalR, with a low identical match and e-value and high query coverage in the metagenome was selected because it demonstrated considerable activity. GalR shared 65% identity with the GH 27 p

• br Chemistry Analog has been previously reported

  2021-10-29

  

  Chemistry Analog 12 has been previously reported by our group. Experimental procedures for the synthesis and characterization of 13–32 are available in Scheme 1, Schemes S1–S9 and Table S1 in Supplementary data. Preparation of 30 and 31 is depicted in Scheme 1 as the representative example. Commo

• A breakthrough in the understanding of

  2021-10-29

  

  A breakthrough in the understanding of the unique properties of GPX4-downregulation-induced cell death was accomplished when Seiler et al. in 2008 demonstrated the role of 12/15-lipoxygenase (12/15-LOX), a polyunsaturated fatty SecinH3 metabolizing enzyme [92], in the execution of GPX4-knockout-med

• Pentostatin FDP is considered as key intermediate

  2021-10-29

  

  FDP is considered as key intermediate in the isoprenoid biosynthetic pathway, since it is the common precursor of polyisoprene units and farnesylated proteins (Cao et al., 2012). In order to understand the role of FDP gene in rubber-producing plants it is of critical importance to Pentostatin and c

• HCC metastasis is a multistep multifactorial process includi

  2021-10-29

  

  HCC metastasis is a multistep, multifactorial process, including adhesion of tumor EIPA to the extracellular matrix (ECM), remodeling and degradation of ECM, invasion through local tissue, intravasation into blood or lymph vessels, and forming new tumors at distant sites [6,7]. Loss of adhesion or

• br Acknowledgments R Dalmann has obtained a

  2021-10-29

  

  Acknowledgments R. Dalmann has obtained a “bourse Cifre” (grant 304/2011) from the ‘Association Nationale de la Recherche Technique’ and Bristol-Myers-Squibb. Introduction Endocannabinoids, their molecular targets (receptors), their synthetic and degrading enzymes and proteins that transport

• Benzene metabolism occurs primarily in the liver

  2021-10-29

  

  Benzene metabolism occurs primarily in the liver where benzene is converted into phenol, catechol, hydroquinone (HQ). HQ is further converted to 1,4-benzoquinone (1,4-BQ) in the bone marrow which is the primary organ of benzene toxicity (Bolton et al., 2000). 1,4-BQ is an important benzene metabolit

• br Autophagy and HBV induced HCC Researchers have demonstrat

  2021-10-28

  

  Autophagy and HBV-induced HCC Researchers have demonstrated downregulation of autophagy in HBV transgenic liver tumors of mouse models and in human HBV-induced HCC specimens. Kotsafti and his colleagues declared that the expression level of BECN1 mRNA in HCC specimens was considerably lower than

• An interesting question is why RhoF has

  2021-10-28

  

  An interesting question is why RhoF has such the slow rate of GDP dissociation. The amino pacritinib mutations in a presumable GDP-binding site of RhoF had only moderate effects on the GDP dissociation (Fig. 3C), which suggests a mechanism involving the global amino acid sequence of RhoF, rather th

• Growing evidence suggests that the glycine site seems to

  2021-10-28

  

  Growing evidence suggests that the glycine site seems to play a pivotal role in NMDAR-related function. For example, it ACY-241 has been demonstrated in a hippocampal slice study that the glycine site sub-serves the spatiotemporal detection of synaptic activity (Li et al., 2009). Moreover, mice wit

• br Conclusion br Acknowledgments br Introduction Throughout

  2021-10-28

  

  Conclusion Acknowledgments Introduction Throughout history, there is literature that supports the notion that animals can be perceived as “healing”. Overall, there is an increased interest in the general field of Animal Assisted Therapy (AAT). Though the field of equine-facilitated psychoth

15521 records 587/1035 page Previous Next First page 上5页 586587588589590 下5页 Last page