• Ionomycin Calcium Salt: Unlocking Calcium Signaling for P...

  2025-09-30

  Discover how ionomycin calcium salt, a potent calcium ionophore, uniquely modulates intracellular Ca2+ dynamics to inhibit tumor growth and drive apoptosis in cancer cells. This in-depth guide explores advanced mechanisms and translational cancer research applications, offering fresh perspectives distinct from existing resources.

• Filipin III in Translational Cholesterol Research: From M...

  2025-09-29

  Explore how Filipin III, a polyene macrolide antibiotic, enables advanced cholesterol detection in membranes and illuminates cholesterol-driven disease mechanisms. This in-depth article uniquely connects membrane cholesterol visualization with translational insights into metabolic dysfunction and liver pathology.

• SIS3: Targeting Smad3 for Next-Generation Fibrosis and Os...

  2025-09-28

  Discover how SIS3, a selective Smad3 inhibitor, advances fibrosis and osteoarthritis research by precisely modulating the TGF-β/Smad signaling pathway. This in-depth analysis explores novel molecular mechanisms and translational applications, offering unique insights beyond existing SIS3 reviews.

• Pifithrin-α (PFTα): Novel Insights into p53 Inhibition fo...

  2025-09-27

  Explore the unique role of Pifithrin-α as a p53 inhibitor in modulating ferroptosis and protecting against neurotoxic insults. This article provides advanced, application-driven insights into p53-dependent apoptosis inhibition and DNA damage response modulation.

• Nonivamide (Capsaicin Analog): TRPV1 Agonist in Neuroimmu...

  2025-09-26

  Explore how Nonivamide, a capsaicin analog and TRPV1 receptor agonist, uniquely bridges neuroimmune modulation and targeted cancer research. This article offers a novel, integrated perspective on Nonivamide’s anti-proliferative and inflammation-regulating mechanisms for advanced oncology and neurobiology applications.

• Phosbind Acrylamide: Precision Phosphorylation Analysis W...

  2025-09-25

  Discover how Phosbind Acrylamide, a phosphate-binding reagent, revolutionizes phosphorylation analysis by enabling antibody-free detection and mechanistic insights into complex signaling pathways. This article uniquely explores processive multisite phosphorylation and dynamic signaling events, advancing beyond standard workflows.

• Nonivamide: Precision Targeting of TRPV1 for Cancer and N...

  2025-09-24

  Explore how Nonivamide, a potent capsaicin analog, uniquely leverages TRPV1 receptor agonism for advanced cancer research and neuroimmune modulation. Discover mechanistic insights, translational applications, and new perspectives not covered in existing literature.

• AZD0156: Unraveling ATM Inhibition and Metabolic Adaptati...

  2025-09-23

  Explore how AZD0156, a potent and selective ATM kinase inhibitor, not only modulates DNA damage response but also reveals novel metabolic vulnerabilities in cancer cells. This article highlights recent research on ATM inhibition, metabolic adaptation, and the implications for cancer therapy research.

• br Introduction Alzheimer s disease AD is

  2025-03-03

  

  Introduction Alzheimer's disease (AD) is a neurodegenerative disorder and the leading cause of dementia. It is characterized by progressive and irreversible damage to different Trequinsin hydrochloride areas, resulting in cognitive impairment and behavioral changes (O'Neill, 2013, De Strooper an

• br Development of lorlatinib from crizotinib to a clinical

  2025-03-03

  

  Development of lorlatinib from crizotinib (1) to a clinical candidate (6) Xalkori (1, PF-02341066, crizotinib), was the first-in-class ALK inhibitor approved by the Unites States Food and Drug Administration (FDA) in 2011 as a first-line treatment for ALK+- NSCLC patients. This section describes

• An important and well documented pathway involved in

  2025-03-03

  

  An important and well-documented pathway involved in cellular growth and proliferation is the mTOR-mediated synthesis of proteins and lipids [7,13,14]. Although found to be tissue specific or context specific regulation, it has always been observed that either one or both the mTOR complexes regulate

• The reduced IFN production seen with BPAL primed splenocytes

  2025-03-03

  

  The reduced IFNγ production seen with BPAL10-primed splenocytes could potentially be attributed to the impaired intracellular survival of B. pertussis, thereby leading to a weakened induction of cell-mediated immunity. Earlier studies have suggested an antimicrobial role of IFNγ in mediating the el

• ADA catalyzes the deamination of adenosine and deoxyadenosin

  2025-03-03

  

  ADA catalyzes the deamination of adenosine and deoxyadenosine into their respective inosine nucleoside (Cristalli et al., 2001). This conversion is an initial step in a series of reactions responsible for lymphocyte proliferation and differentiation. Moreover, ADA is considered an indicator of cellu

• Because activation of HT A receptor is capable of facilitati

  2025-03-03

  

  Because activation of 5-HT2A receptor is capable of facilitating dopamine cell activity and dopamine release (Bortolozzi et al., 2003), and this action of dopamine is known to mediate rat maternal behavior, especially maternal motivation (Afonso et al., 2007, Febo et al., 2010, Li and Fleming, 2003,

• The most potent compounds within the

  2025-03-03

  

  The most potent compounds within the current series of compounds were therefore , , , , and , with Ramiprilat possessing the best selectivity towards the lyase reaction in comparison to the hydroxylase reaction, indeed, this compound was found to possess an IC value of 1210nM against the 17α-OHas

15426 records 2/1029 page Previous Next 12345 下5页 Last page