• In the presence of detrimental conditions such as

  2024-06-14

  

  In the presence of detrimental conditions, such as inflammation, hypoxia, ischemia trauma or neoplastic milieu, the extracellular levels of adenosine increase massively, reaching micromolar range [51,52]. In these pathological contexts, adenosine accumulation stems from increased extracellular depho

• br Actin cytoskeleton in protrusion Pushing force driving

  2024-06-14

  

  Actin cytoskeleton in protrusion Pushing force driving membrane protrusion is generated by polymerizing lumiracoxib filaments organized either into branched networks or parallel bundles. Branched networks are assembled through Arp2/3 complex-dependent actin nucleation and drive protrusion of lame

• br Acknowledgments The authors would like to

  2024-06-14

  

  Acknowledgments The authors would like to thank Ms. Ashley Davis for her administrative assistance in preparing this article and Mr. Dan Beck for his artistic contributions to Fig. 1. Introduction Acetylcholine is the most abundant neurotransmitter in the central nervous system (CNS) of insec

• br Funding This work was supported

  2024-06-14

  

  Funding This work was supported by Arena Pharmaceuticals, Inc, San Diego, CA, USA. Introduction 5-hydroxytryptamine 1B (5-HT1B) receptors are widely distributed in the central nervous system (CNS); they have various modulatory functions in drug reinforcement, appetitive behaviors, stress, moo

• Acknowledgments br P c is expressed

  2024-06-14

  

  Acknowledgments P450c17 is expressed in several steroidogenic tissues, including the adrenal cortex, the ovary, and the testes (). Thus, 17α-hydroxylase/17,20-lyase is a key enzyme required for the production of both cortisol and sex steroids. This enzyme defect blocks the synthesis of cortisol,

• Acknowledgments br P c is expressed

  2024-06-14

  

  Acknowledgments P450c17 is expressed in several steroidogenic tissues, including the adrenal cortex, the ovary, and the testes (). Thus, 17α-hydroxylase/17,20-lyase is a key enzyme required for the production of both cortisol and sex steroids. This enzyme defect blocks the synthesis of cortisol,

• rat 4 br Introduction The process of mitosis is highly compl

  2024-06-14

  

  Introduction The process of mitosis is highly complex and tightly regulated. This phase of the rat 4 resulted in two identical daughter cells. The aurora kinases (aurora A, B, and C) are a family of three highly homologous serine-threonine protein kinases that play a key role in regulating the mi

• Introduction Lipoxygenases LOXs are key enzymes

  2024-06-14

  

  Introduction Lipoxygenases (LOXs) are key enzymes that catalyze the polyunsaturated fatty acids (PUFAs) such as arachidic perifosine (AA), linoleic acid (LA) and others unsaturated fatty acids (Brash, 1999). LOXs are expressed in immune, neural, epithelial, tumor cells and other cells (Claesson, 2

• These recommendations may be useful

  2024-06-14

  

  These recommendations may be useful for the future to avoid misleading reports and pairings. However, the existing literature can also hold back current research on some given orphans. Before entering into drug development or further physiological conceptual framework, these pairings should be thoro

• br Materials and methods br Results A first series

  2024-06-13

  

  Materials and methods Results A first series of experiments explored whether the Ampkα1 isoform is involved in the regulation of cardiac Pkcζ. To this end, HL-1 cardiomyocytes were transfected with a construct encoding constitutively active Prkaa1T183D (CAα1) or with the empty vector as contro

• In a human intervention study

  2024-06-13

  

  In a human intervention study, blood GSH levels were evaluated over 6 wk in 18 male participants subjected to strenuous aerobic training and a dietary supplement of 1 g of WPI/kg of body mass per day. Blood GSH levels were significantly lower in those subjects who performed exercise that those who d

• br Special report Financial and personal

  2024-06-13

  

  Special report – Financial and personal benefits of early diagnosis Acknowledgments The Alzheimer’s Association acknowledges the contributions of Joseph Gaugler, Ph.D., Bryan James, Ph.D., Tricia Johnson, Ph.D., Allison Marin, Ph.D., and Jennifer Weuve, M.P.H., Sc.D., in the preparation of 201

• Various compounds have been designed to inhibit

  2024-06-13

  

  Various compounds have been designed to inhibit aldose reductase (AR) [12]. These compounds can be classified into two main categories, the first category comprises those containing a carboxylic nhs chemical mg moiety, for example, 3-thiazolidineacetic acid derivative, which has been reported to be

• br Mechanisms for regulation of intracellular cholesterol ho

  2024-06-13

  

  Mechanisms for regulation of intracellular cholesterol homeostasis Cells maintain intracellular free cholesterol levels and distribution within stringent tolerances by several mechanisms [55]: (1) uptake of native LDL (the major extracellular carrier of cholesterol) by LDL receptors and modified

• Based on the observation that antipsychotic

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  Based on the observation that antipsychotic drugs increase 5-HT1A–D2 heteromerization level (Łukasiewicz et al., 2016), we set out to compare the effect of paroxetine to that of risperidone. Paroxetine, a potent SSRI, is very effective in the treatment of depression and anxiety disorders, e.g., gene

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